Lactobacillus plantarum and Lactobacillus brevis alleviate intestinal inflammation and microbial disorder induced by ETEC in a murine model. - GreenMedInfo Summary

The purpose of this research is to explore the positive effects ofandon the tissue damage and microbial community in mice challenged by Enterotoxigenic(ETEC). Twenty-four mice were divided into four groups randomly: the CON group, ETEC group, LP-ETEC group and LB-ETEC group. Our results demonstrated that, compared with the ETEC group, the LP-ETEC and LB-ETEC groups experienced less weight loss and morphological damage of the jejunum. We measured proinflammatory factors of colonic tissue and found thatandinhibited the expression of proinflammatory factors such as IL-, TNF-, and IL-6 and promoted that of the tight junction protein such as claudin-1, occludin, and ZO-1. Additionally,andaltered the impact of ETEC on the intestinal microbial community of mice, significantly increased the abundance of probiotics such as, and reduced that of pathogenic bacteria such as,,, and. Therefore, we believe thatandcan stabilize the intestinal microbiota and inhibit the growth of pathogenic bacteria, thus protecting mice from the gut inflammation induced by ETEC.