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Abstract Title:

Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen induced allergic rhinitis in mice.

Abstract Source:

J Appl Microbiol. 2017 Nov 12. Epub 2017 Nov 12. PMID: 29130606

Abstract Author(s):

S-P Choi, H-N Oh, C-Y Choi, H Ahn, H S Yun, Y M Chung, B Kim, S J Lee, T Chun

Article Affiliation:

S-P Choi

Abstract:

AIMS: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis.

METHODS AND RESULTS: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness (AHR), and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage (BAL) fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ), and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE, and BP-specific serum IgG1 were decreased, whereas secretion of IFN-γ and BP-specific serum IgG2a were augmented upon administration of CJLP133 and CJLP243 in mice.

CONCLUSION: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response.

SIGNIFICANCE AND IMPACT OF THE STUDY: Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model. This article is protected by copyright. All rights reserved.

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