Abstract Title:

DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study.

Abstract Source:

Benef Microbes. 2019 Apr 19 ;10(4):355-373. Epub 2019 Mar 18. PMID: 30882244

Abstract Author(s):

H X Chong, N A A Yusoff, Y-Y Hor, L-C Lew, M H Jaafar, S-B Choi, M S B Yusoff, N Wahid, M F I L Abdullah, N Zakaria, K-L Ong, Y-H Park, M-T Liong

Article Affiliation:

H X Chong


Probiotics have been reported to exert beneficial effects along the gut-brain axis. This randomised, double-blind and placebo-controlled human study aimed to evaluate such properties ofDR7 and its accompanying mechanisms in stressed adults. One hundred and eleven (n=111; DR7 n=56, placebo n=55) stressed adults were recruited based on moderate stress levels using the PSS-10 questionnaire. The consumption of DR7 (1×10cfu/day) for 12 weeks reduced symptoms of stress (=0.024), anxiety (=0.001), and total psychological scores (=0.022) as early as 8 weeks among stressed adults compared to the placebo group as assessed by the DASS-42 questionnaire. Plasma cortisol level was reduced among DR7 subjects as compared to the placebo, accompanied by reduced plasma pro-inflammatory cytokines, such as interferon-γ and transforming growth factor-α and increased plasma anti-inflammatory cytokines, such as interleukin 10 (<0.05). DR7 better improved cognitive and memory functions in normal adults (>30 years old), such as basic attention, emotional cognition, and associate learning (<0.05), as compared to the placebo and young adults (<30 years old). The administration of DR7 enhanced the serotonin pathway, as observed by lowered expressions of plasma dopamineβ-hydroxylase (DBH), tyrosine hydroxylase (TH), indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine receptor-6, while stabilising the dopamine pathway as observed via stabilised expressions of TH and DBHover 12 weeks as compared to the placebo (<0.05). Our results indicated that DR7 fulfil the requirement of a probiotic strain as per recommendation of FAO/WHO and could be applicable as a natural strategy to improve psychological functions, cognitive health and memory in stressed adults.

Study Type : Human Study
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Diseases : Anxiety

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