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Abstract Title:

Lactoferrin as a regenerative agent: the old-new panacea?

Abstract Source:

Pharmacol Res. 2021 Mar 17:105564. Epub 2021 Mar 17. PMID: 33744427

Abstract Author(s):

Artem A Antoshin, Anastasia I Shpichka, Guilin Huang, Kuo Chen, Pengwei Lu, Andrey A Svistunov, Alexey V Lychagin, Marina M Lipina, Mikhail Y Sinelnikov, Igor V Reshetov, Peter S Timashev

Article Affiliation:

Artem A Antoshin

Abstract:

Lactoferrin (Lf) possesses various biological properties and therapeutic potentials being a perspective anti-inflammatory, antibacterial, antiviral, antioxidant, antitumor, and immunomodulatory agent. A significant body of literature has also demonstrated that Lf modulates regenerative processes in different anatomical structures, such as bone, cartilage, skin, mucosa, cornea, tendon, vasculature, and adipose tissue. Hence, this review collected and analyzed the data on the regenerative effects of Lf, as well as paid specific attention to their molecular basis. Furthermore, tissue and condition-specific activities of different Lf types as well as problems of their delivery to the targeted organs were discussed. The authors strongly hope that this review will stimulate researchers to focus on the highlighted topics thus accelerating the progress of Lf's wider clinical application.

Study Type : Review
Additional Links
Pharmacological Actions : Regenerative : CK(408) : AC(172)
Additional Keywords : Bodily Tissue Regeneration

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