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Article Publish Status: FREE
Abstract Title:

Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer.

Abstract Source:

Int J Mol Sci. 2019 Nov 25 ;20(23). Epub 2019 Nov 25. PMID: 31775230

Abstract Author(s):

Brigitta Kis, Feng Chen Ifrim, Valentina Buda, Stefana Avram, Ioana Zinuca Pavel, Diana Antal, Virgil Paunescu, Cristina Adriana Dehelean, Florina Ardelean, Zorita Diaconeasa, Codruta Soica, Corina Danciu

Article Affiliation:

Brigitta Kis

Abstract:

L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present inL., namely, cannabidiol (CBD) andΔ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.

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