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Abstract Title:

Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia.

Abstract Source:

Eur Neurol. 2009 ;62(6):356-61. Epub 2009 Sep 26. PMID: 19786780

Abstract Author(s):

Roberto Fancellu, Davide Pareyson, Elena Corsini, Ettore Salsano, Matilde Laurà, Gaetano Bernardi, Carlo Antozzi, Francesca Andreetta, Maurizio Colecchia, Stefano Di Donato, Caterina Mariotti

Article Affiliation:

SOD Genetica delle Malattie Neurodegenerative e Metaboliche, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italia.

Abstract:

In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women had anti-Yo antibodies; two patients had anti-gliadin antibodies in the presence of celiac disease; one patient had a complex autoimmune disorder associated with anti-Ro-52/SS-A and anti-muscle-specific kinase antibodies, and a patient developed subacute cerebellar syndrome associated with the presence of a prostatic adenocarcinoma and atypical antibodies reacting both with cerebellar tissue and with the prostatic tumor. Our study confirms previous findings in paraneoplastic syndromes, and indicates that at least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms.

Study Type : Human: Case Report
Additional Links
Problem Substances : Gliadin : CK(819) : AC(116)
Adverse Pharmacological Actions : Immunoreactive : CK(167) : AC(33)

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