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Abstract Title:

Bioactive coumarins from Boenninghausenia sessilicarpa.

Abstract Source:

J Asian Nat Prod Res. 2007 Jan-Feb;9(1):59-65. PMID: 17365191

Abstract Author(s):

Q-Y Yang, X-Y Tian, W-S Fang

Article Affiliation:

Q-Y Yang

Abstract:

Bioassay guided fractionation of Boenninghausenia sessilicarpa (Rutaceae) resulted in the isolation of a new dimeric coumarin glucoside 9'-methoxyl rutarensin (1) and a cytotoxic compound rutamarin (4), as well as an antivirus component leptodactylone (8), together with six known coumarins. Their structures were elucidated by 1D- and 2D NMR spectroscopy and ESI-MS analyses, respectively. Rutamarin (4) showed significant inhibitory activities against A-549, Bel-7402, HepG-2 and HCT-8 tumour cell lines with IC50s of 1.318, 2.082, 2.306 and 2.497 microg/ml. In addition, leptodactylone (8) showed potent protective activity on cells infected by SARS-CoV with ratio of 60% at 100 microg/ml.

Study Type : In Vitro Study

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