Lichen substances have anti-angiogenic and antiproliferative properties. - GreenMedInfo Summary
Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid.
Z Naturforsch C. 2015 ;70(5-6):159-64. PMID: 26136299
Ayşe Tansu Koparal
The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-angiogenic substance because of its low cytotoxicity and stronger anti-angiogenic activity on the HUVEC cell line.