Abstract Title:

Antimycobacterial activity of lichen substances.

Abstract Source:

Phytomedicine. 2009 Aug 13. PMID: 19683421

Abstract Author(s):

N K Honda, F R Pavan, R G Coelho, S R de Andrade Leite, A C Micheletti, T I B Lopes, M Y Misutsu, A Beatriz, R L Brum, C Q F Leite

Abstract:

We describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity. The depsides (atranorin, diffractaic and lecanoric acids), depsidones (protocetraric, salazinic, hypostictic and norstictic acids), xanthones (lichexanthone and secalonic acid), and usnic acid, as well seven orsellinic acid esters, five salazinic acid 8',9'-O-alkyl derivatives and four lichexanthone derivatives, were evaluated for their activity against Mycobacterium tuberculosis. Diffractaic acid was the most active compound (MIC value 15.6mug/ml, 41.6muM), followed by norstictic acid (MIC value 62.5mug/ml, 168muM) and usnic acid (MIC value 62.5mug/ml, 182muM). Hypostictic acid (MIC value 94.0mug/ml, 251muM) and protocetraric acid (MIC value 125mug/ml, 334muM) showed moderate inhibitory activity. The other compounds showed lower inhibitory activity on the growth of M. tuberculosis, varying from MIC values of 250 to 1370muM.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.