Article Publish Status: FREE
Abstract Title:

Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines.

Abstract Source:

Molecules. 2018 Aug 13 ;23(8). Epub 2018 Aug 13. PMID: 30104527

Abstract Author(s):

Tatiana Takahasi Komoto, Tayná Minervina Bernardes, Thaís Balthazar Mesquita, Luis Felipe Buso Bortolotto, Gabriel Silva, Tamires Aparecida Bitencourt, Seung Joon Baek, Mozart Marins, Ana Lúcia Fachin

Article Affiliation:

Tatiana Takahasi Komoto


In the present investigation,-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.

Study Type : In Vitro Study

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