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Abstract Title:

Licochalcone B Extracted from Glycyrrhiza uralensis Fisch Induces Apoptotic Effects in Human Hepatoma Cell HepG2.

Abstract Source:

J Agric Food Chem. 2019 Mar 27 ;67(12):3341-3353. Epub 2019 Mar 12. PMID: 30835110

Abstract Author(s):

Jun Wang, Ai-Mei Liao, Kiran Thakur, Jian-Guo Zhang, Ji-Hong Huang, Zhao-Jun Wei

Article Affiliation:

Jun Wang

Abstract:

The present study explored the molecular mechanism by which licochalcone B induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Initial extraction and identification were performed by HPLC, UPLC-TOF-MS/MS, and NMR analysis, respectively. Licochalcone B inhibited the HepG2 growth with IC(110.15μM) after 24 h, caused morphological distortion, and seized the cell cycle in the G2/M phase (cell arrest in G2/M:43.1 ± 2.2% for 120 μM versus 23.7 ± 1.2% for control), as well as induced apoptosis and intracellular ROS generation. Furthermore, exposure to licochalcone B markedly affected the cell cycle (up/down regulation) at mRNA and protein levels. Apoptosis was induced through the activation of receptor-mediated and mitochondrial pathways. The inhibition of Caspase 8 and Caspase 9 proteins abolished the licochalcone B induced apoptosis. The present work suggested that licochalcone B may further be identified as a potent functional food component with specific health benefits.

Study Type : In Vitro Study

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Sayer Ji
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