n/a
Abstract Title:

Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo.

Abstract Source:

Antiviral Res. 2021 11 ;195:105091. Epub 2021 May 25. PMID: 34044060

Abstract Author(s):

Yiming Cao, En Lei, Xiaolong Wang, Xiangyun Qi, Lei Li, Jin Ren, Jing Yang, Shengqi Wang

Article Affiliation:

Yiming Cao

Abstract:

Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-mouth disease (HFMD) and causes serious neurological complications. However, no effective therapy is currently available for treating these infections. Therefore, effective drugs to prevent and treat EV-A71 infections are urgently needed. Here, we demonstrated that treatment with Licochalcone A (LCA) significantly inhibited EV-A71 replication in a dose-dependent manner, with an ECof 9.30 μM in RD cells and 5.73 μM in Vero cells. The preliminary results on the inhibition mechanism showed that LCA exerted antiviral effects by interfering with the early step of viral replication. We further demonstrated that LCA showed potent antiviral activity against many enteroviruses, including EV-A71 (strain C4), EV-A71 (strain H), and coxsackievirus A16 (CV-A16). Furthermore, LCA could effectively prevent the clinical symptoms and death of virus infected mice and decreased viral load in EV-A71-infected mice. Taken together, our studies showed for the first time, that LCA is a promisingEV-A71 inhibitor and provide important information for the clinical development of LCA as a potential new anti-EV-A71 agent.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1615)

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.