[The anti-respiratory syncytial virus (RSV) effect of Radix Glycyrrhizae in vitro].
Zhong Yao Cai. 2004 Jun;27(6):425-7. PMID: 15524297
College of Public Health, Harbin Medical University, Harbin.
OBJECTIVE: To develop safe and effective anti-RSV new medicine from Radix Glycyrrhizae. METHOD: The anti-RSV effect of Radix Glycyrrhizae in Hela cell culture was observed by means of the inhibition of cytopathic effect. RESULT: In Hela cell culture, Radix Glycyrrhizae was found to be a inhibitor of RSV in a concentration-dependent manner. The median toxic concentration (TC50) of Radix Glycyrrhizae was 3.43 g/L, the median effective concentration (EC50) of Radix glycyrrhizae against replication of the Long strain of RSV in Hela cells were 0.2535 g/L, the selectivity index (TI = TC50/EC50) is 13.53. In time of addition experiment, Radix Glycyrrhizae inhibited the effect of RSV in Hela cells when it was added at 0 h, 2 h, 4 h, 6 h, 8 h after virus infection. CONCLUSION: In Hela cell culture, Radix Glycyrrhizae was found to be a inhibitor of RSV, there are many ways in the mechanisms.