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Abstract Title:

Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.

Abstract Source:

J Nat Prod. 2009 Jun;72(6):1133-41. PMID: 19413342

Abstract Author(s):

Xiao-Nian Li, Jian-Xin Pu, Xue Du, Liu-Meng Yang, Hui-Mei An, Chun Lei, Fei He, Xiao Luo, Yong-Tang Zheng, Yang Lu, Wei-Lie Xiao, Han-Dong Sun

Abstract:

Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)

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