Abstract Title:

Reciprocal effects ofα-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats.

Abstract Source:

Menopause. 2011 Apr 18. Epub 2011 Apr 18. PMID: 21505371

Abstract Author(s):

Pao-Yun Cheng, Yen-Mei Lee, Mao-Hsiung Yen, Jia-Chi Peng, Kwok-Keung Lam

Article Affiliation:

From the 1Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung; 2Department of Pharmacology, National Defense Medical Center; 3Department of Pharmacology, Taipei Medical University, Taipei; and 4Department of Anesthesiology, Catholic Mercy Hospital, Hsin-Chu, Taiwan.

Abstract:

OBJECTIVE:: Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in regulating whole-body energy homeostasis. The aim of this study was to investigate dietaryα-lipoic acid (α-LA) supplementation on the activation of AMPK in both central and peripheral tissues in obese rats induced by ovariectomy. METHODS:: Ovariectomized (Ovx) rats were treated with α-LA (200 mg/kg) 3 to 10 weeks after surgery. Body weight, food intake, fat mass, phosphorylated AMPKα(pAMPKα), and phosphorylated acetyl-CoA carboxylase (ACC) protein expression in both the hypothalamus and white adipose tissue (WAT) as well as plasma leptin and adiponectin levels were measured in rats after either Ovx or sham operations. RESULTS:: Compared with control rats, ovariectomy led to increased body weight, food intake, and WAT mass 2 to 10 weeks after surgery. Furthermore, plasma leptin and adiponectin levels as well as hypothalamic pAMPKα expression were significantly increased after ovariectomy, accompanied by a reduction in pAMPKα expression in WAT after ovariectomy. However, after treatment with α-LA, the elevation of leptin and adiponectin levels and the activation of hypothalamic AMPKα and ACC, as induced by ovariectomy, were significantly suppressed. Meanwhile, decreased fat mass and increased pAMPKα and phosphorylated ACC expression in the WAT were observed inOvx rats treated with α-LA. CONCLUSIONS:: α-LA significantly decreased appetite and fat accumulation, possibly through the regulation of central and peripheral AMPK activities in rats. Therefore, this study provides a rationale for the therapeutic use of α-LA for obesity in postmenopausal women.

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