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Article Publish Status: FREE
Abstract Title:

Litchi seed extract inhibits epidermal growth factor receptor signaling and growth of Two Non-small cell lung carcinoma cells.

Abstract Source:

BMC Complement Altern Med. 2017 Jan 5 ;17(1):16. Epub 2017 Jan 5. PMID: 28056952

Abstract Author(s):

Yuan-Chiang Chung, Chin-Hui Chen, Yu-Ting Tsai, Chih-Cheng Lin, Jyh-Ching Chou, Ting-Yu Kao, Chiu-Chen Huang, Chi-Hsuan Cheng, Chih-Ping Hsu

Article Affiliation:

Yuan-Chiang Chung

Abstract:

BACKGROUND: Litchi seeds possess rich amounts of phenolics and have been shown to inhibit proliferation of several types of cancer cells. However, the suppression of EGFR signaling in non-small cell lung cancer (NSCLC) by litchi seed extract (LCSE) has not been fully understood.

METHODS: In this study, the effects of LCSE on EGFR signaling, cell proliferation, the cell cycle and apoptosis in A549 adenocarcinoma cells and NCI- H661 large-cell carcinoma cells were examined.

RESULTS: The results demonstrated that LCSE potently reduced the number of cancer cells and induced growth inhibition, cell-cycle arrest in the G1 or G2/M phase, and apoptotic death in the cellular experiment. Only low cytotoxicity effect was noted in normal lung MRC-5 cells. LCSE also suppressed cyclins and Bcl-2 and elevated Kip1/p27, Bax and caspase 8, 9 and 3 activities, which are closely associated with the downregulation of EGFR and its downstream Akt and Erk-1/-2 signaling.

CONCLUSION: The results implied that LCSE suppressed EGFR signaling and inhibited NSCLC cell growth. This study provided in vitro evidence that LCSE could serve as a potential agent for the adjuvant treatment of NSCLC.

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