Long-term intake of white tea protected kidney against the oxidative stress. - GreenMedInfo Summary
Long-term intake of white tea prevents oxidative damage caused by adriamycin in kidney of rats.
J Sci Food Agric. 2015 Oct 6. Epub 2015 Oct 6. PMID: 26441376
BACKGROUND: White tea infusion (Camelia sinensis) has antioxidants properties. Contains polyphenols that has been proposed to induced ARE response via NRF2. Adriamycin (ADR) has antitumor properties and oxidative effects. Oxidative stress is related with a variety of kidney diseases. Prevention of the oxidative stress through long-term intake of white tea and the study of the molecular mechanisms involved in protection could be of great interest. Rats were given distilled water, 0.015 or 0.045 g of solid white tea extract x kg(-1) body weight for 12 months. Animals received an injection of ADR. In kidney, oxidative stress parameters were measured, the expressions of nuclear factor E2-related factor 2 (Nrf2), and detoxifying and antioxidants genes were analysed, and the activities of CAT, SOD and GR were measured.
RESULTS: ADR administration increased oxidative parameters and decreased the antioxidant activity; significantly increased the expression of analysed genes and the activity of CAT and SOD and decreased GR activity. The highest white tea dose protected redox status and inhibited ARE response.
CONCLUSION: Long-term intake of white tea protected kidney against the oxidative stress. ADR activated the ARE response but in animals treated with the highest dose of white tea, this response was inhibited, probably for the antioxidant protection.