Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma. - GreenMedInfo Summary
Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma.
J Clin Exp Hematop. 2021 Sep 10 ;61(3):168-172. Epub 2021 Jun 30. PMID: 34193754
Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for>30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for>42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.