Abstract Title:

Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use.

Abstract Source:

J Pharm Pharmacol. 2021 Feb 22. Epub 2021 Feb 22. PMID: 33793790

Abstract Author(s):

Larissa Selbach Dries, Rochelli Haefliger, Bruna Sherer Seibert, Angélica Gewehr de Lima, Caroline de Oliveira Cardoso, Magda Susana Perassolo

Article Affiliation:

Larissa Selbach Dries


OBJECTIVES: To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months.

METHODS: A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluationof malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma.

KEY FINDINGS: A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairmentson executive functions, automatic and attentional processing.

CONCLUSIONS: Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline.

Study Type : Human Study

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Sayer Ji
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