Abstract Title:

Evaluation of radicals scavenging, immunity-modulatory and antitumor activities of longan polysaccharides with ultrasonic extraction on in S180 tumor mice models.

Abstract Source:

Int J Biol Macromol. 2010 Oct 1;47(3):356-60. Epub 2010 Jun 4. PMID: 20685359

Abstract Author(s):

Kui Zhong, Qiang Wang, Yin He, Xuanhui He

Article Affiliation:

Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China.

Abstract:

Longan (Dimocarpus longan Lour.) is used as a traditional edible and medicinal material in China. In this paper, the effects of polysaccharides from longan pulp with ultrasonic extraction (UELP) on the radicals scavenging, immunity-modulatory and antitumor activities in S180 tumor mice models were investigated. UELP showed excellent scavenging activity on the hydroxyl radicals and a,a-diphenyl-1-picrylhydrazyl (DPPH) radicals, and obtained the almost complete scavenging effect. UELP with medium-dose (200mg/kg) and low-dose (100mg/kg) had potent immune-modulatory effects in S180 tumor mice model and exhibited significant effect on delayed-type hypersensitivity (DTH) response, macrophage phagocytosis and ConA-stimulated splenocyte proliferation as compared with model control treatment (p<0.01). The results still showed that UELP had great antitumor effects, and maximum inhibition rate was obtained at medium-dose and low-dose (200 and 100mg/kg).

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.