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Abstract Title:

Niacin modulates macrophage polarization in Parkinson's disease.

Abstract Source:

J Neuroimmunol. 2018 Jul 15 ;320:76-79. Epub 2018 May 4. PMID: 29759143

Abstract Author(s):

Chandramohan Wakade, Banabihari Giri, Aneeq Malik, Hesam Khodadadi, John C Morgan, Raymond K Chong, Babak Baban

Article Affiliation:

Chandramohan Wakade

Abstract:

Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

Study Type : Human Study

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