Abstract Title:

Serum uric acid and lipid profiles in sporadic Creutzfeldt-Jakob disease.

Abstract Source:

Clin Biochem. 2016 Feb ;49(3):292-4. Epub 2015 Oct 8. PMID: 26454226

Abstract Author(s):

Shuai Chen, Shuang He, Jun-Kui Shang, Ming-Ming Ma, Chang-Shui Xu, Xiao-Hong Shi, Jie-Wen Zhang

Article Affiliation:

Shuai Chen

Abstract:

OBJECTIVES: Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disease affecting the central nervous system. Brain lipid homeostasis and oxidative stress seem to play an important role in the disease pathogenesis. But little was known whether serum lipids and uric acid (a natural antioxidant) levels changed in patients with prion disease.

DESIGN AND METHODS: Here we retrospectively reviewed and compared the serum lipids and uric acid levels of 19 probable sporadic CJD patients and 26 healthy control subjects.

RESULTS: We found that the serum uric acid levels in sporadic CJD patients were significantly lower than that in controls (P=0.01). Serum triglycerides, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and apolipoprotein A1 (ApoA1) were similar in sporadic CJD patients and controls. However, LDL/HDL ratio was lower in sporadic CJD patients (P=0.003).

CONCLUSIONS: The low serum uric acid and LDL/HDL ratio levels in sporadic CJD indicate that dysfunction in the lipid homeostasis and oxidative stress is associated with sporadic prion disease.

Study Type : Human Study

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