Low zinc and high copper may contribute to certain types of gastric cancer. - GreenMedInfo Summary
[Serum and tissue copper, zinc and selenium levels in patients with gastric carcinoma].
Zhonghua Zhong Liu Za Zhi. 1991 Mar;13(2):93-6. PMID: 1879301
Serum and tissue copper, zinc and selenium levels were measured in patients with gastric carcinoma. The mean level of serum copper in patients with gastric carcinoma (42 cases) was 950 +/- 130 ug/L, which was higher than 800 +/- 70 ug/L of the control (30 cases, P less than 0.05). The serum selenium level in patients with gastric carcinoma was lower than that in the control (63 +/- 15 ug/L vs 85 +/- 8 ug/L, P less than 0.05). No significant difference in serum zinc level was found between the patient and control groups. In cancer tissues, the mean concentration of copper was 13.5 +/- 2.6 micrograms/g dry weight, which was much higher than 7.1 +/- 1.6 micrograms/g dry weight in the intact gastric mucosa (P less than 0.01). The activity of superoxide dismutase (SOD) in cancer tissue was 95 +/- 10 u/mg-protein, which was lower than 124 +/- 12 u/mg-protein in the intact gastric mucosa (P less than 0.05). The above changes may facilitate production of free radicals, tissue damage and carcinogenesis.