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Article Publish Status: FREE
Abstract Title:

Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs.

Abstract Source:

J Cancer. 2018 ;9(20):3669-3675. Epub 2018 Sep 8. PMID: 30405835

Abstract Author(s):

Yansong Pu, Tao Zhang, Jianhua Wang, Zhijun Mao, Baojun Duan, Yanbin Long, Fei Xue, Dong Liu, Sida Liu, Zengzhan Gao

Article Affiliation:

Yansong Pu

Abstract:

Accumulating studies confirmed that luteolin, a common dietary flavonoid which is widely distributed in plants and has diverse beneficial biological function, including anti-oxidant, anti-inflammation and anticancer properties. However, the detail mechanisms of luteolin on GC are poorly understood. Here, we investigated the anticancer effect of luteolin in GC cellsand. Luteolin reduced the cell viability in a time and dose-dependent manner. Luteolin significantly inhibited cell cycle progress, colony formation, proliferation, migration, invasion and promoted apoptosisand. Luteolin also regulated these biological effects associated regulators. Mechanically, luteolin treatment regulated Notch1, PI3K, AKT, mTOR, ERK, STAT3 and P38 signaling pathways and modulated a series of miRNAs expression. These findings provide novel insight into the molecular function of luteolin which suggest its potential as a therapeutic agent for human GC.

Study Type : In Vitro Study

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Sayer Ji
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