n/a
Abstract Title:

Lycium barbarum Polysaccharide Ameliorates Sjögren's Syndrome in a Murine Model.

Abstract Source:

Mol Nutr Food Res. 2021 06 ;65(11):e2001118. Epub 2021 May 5. PMID: 33825332

Abstract Author(s):

Yifan Wang, Jia Xiao, Yuchen Duan, Miao Miao, Bo Huang, Jiali Chen, Gong Cheng, Xingyu Zhou, Yuebo Jin, Jing He, Zhanguo Li, Kwok-Fai So

Article Affiliation:

Yifan Wang

Abstract:

SCOPE: This study aims to evaluate the therapeutic efficacy and mechanisms of Lycium barbarum polysaccharide (LBP) in primary Sjögren's syndrome (pSS).

METHODS AND RESULTS: Non-obese diabetic mice (the pSS model) are randomly divided into four groups: Low dose LBP (LBP.L, 5 mg kg d), high dose LBP (10 mg kg d), low dose interleukin (IL)-2 (25 000 IU/d), and control (saline water). Drugs were treated for 12 weeks. LBP.L significantly reduces the salivary gland inflammation compared with the control group (histological score pvs = 0.019; foci number: pvs = 0.038). LBP.L also remarkably reduces the effector follicular helper T (Tfh) cells and the CD4IL-17Ahelper T (Th17) cells in both spleen and cervical lymph node (cLN) cells. Additionally, the ratios of regulatory T cell (Treg)/Tfh cells and Treg/Th17 cells are substantially increased in mice treated with LBP.L in both spleen and cLNs. LBP also inhibits Th17 and Tfh cells and markedly increases the Treg/Tfh ratio in human peripheral blood mononuclear cells.

CONCLUSION: LBP.L inhibits the progression of pSS in mice, associated with modulation of T cell differentiation.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.