n/a
Abstract Title:

Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis.

Abstract Source:

Int J Obes (Lond). 2019 09 ;43(9):1735-1746. Epub 2018 Dec 11. PMID: 30538283

Abstract Author(s):

Jia Wang, Zhuo Wang, Bing Li, Yu Qiang, Tian Yuan, Xintong Tan, Zihan Wang, Zhigang Liu, Xuebo Liu

Article Affiliation:

Jia Wang

Abstract:

BACKGROUND/OBJECTIVES: The aim of the current study was to investigate the inhibitory effect of lycopene (LYC), a major carotenoid present in tomato, on high-fat and high-fructose western diet (HFFD)-induced cognitive impairments and the protective effects on HFFD-elicited insulin resistance, lipid metabolism dysfunction and inflammatory responses in the gut-liver-brain axis.

SUBJECTS/METHODS: We randomly assigned 3-month-old C57BL/6 J mice to three groups with different diets: the control group, HFFD group and HFFD + LYC group (LYC, 0.03% w/w, mixed into high-fat diet) for 10 weeks.

RESULTS: The results of the Y-maze task and Morris water maze tests demonstrated that LYC attenuated HFFD-induced memory loss. Moreover, LYC suppressed HFFD-elicited synaptic dysfunction and increased the expressions of SNAP-25 and PSD-95. Furthermore, LYC ameliorated insulin resistance, lipid metabolism dysfunction and inflammatory responses in the mouse brain and liver. LYC also prevente.d intestinal barrier integrity damages and decreased the level of circulating LPS.

CONCLUSIONS: These results demonstrated that LYC ameliorated HFFD-induced cognitive impairments in a mouse model by improving insulin resistance, lipid metabolism dysfunction and inflammatory responses in the gut-liver-brain axis. These findings indicate that LYC might be a nutritional strategy for western diet-induced dysfunction of the central nervous system.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.