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Article Publish Status: FREE
Abstract Title:

Lycopene inhibits IL-1β-induced inflammation in mouse chondrocytes and mediates murine osteoarthritis.

Abstract Source:

J Cell Mol Med. 2021 Mar 10. Epub 2021 Mar 10. PMID: 33751809

Abstract Author(s):

Jingdi Zhan, Zijian Yan, Xiaojiang Kong, Junling Liu, Zeng Lin, Weihui Qi, Yifan Wu, Jian Lin, Xiaoyun Pan, Xinghe Xue

Article Affiliation:

Jingdi Zhan

Abstract:

Osteoarthritis (OA) is a common chronic degenerative condition in the elderly, in which inflammation plays a key role in disease pathology. Lycopene (Lye), a member of the carotenoid family, has been reported to have anti-inflammatory effects. The purpose of this study was to investigate the effect of Lye on the inflammation of chondrocytes and the mouse OA model. Chondrocytes were treated with interleukin (IL)-1β, and the mouse OA model was induced by the surgical destabilization of the medial meniscus (DMM). The results showed that Lye could inhibit the expression of inflammatory factors and alleviate the degradation of extracellular matrix (ECM). Additionally, Lye could activate the Nrf2/HO-1 pathway and reverse the activations of NF-κB and STAT3 signal pathway induced by IL-1β, suggesting that its anti-inflammatory effect may be mediated via these pathways. The animal experiments showed that Lye could decrease the Osteoarthritis Research Society International (OARSI) scores of the knee, indicating that it could inhibit the occurrence and development of OA in mouse. Overall, our results indicated that Lye might be used as a novel drug for OA treatment.

Study Type : Animal Study

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