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Abstract Title:

Hepatoprotective and antioxidant effects of lycopene in acute cholestasis.

Abstract Source:

Turk J Med Sci. 2015 ;45(4):857-64. PMID: 26422858

Abstract Author(s):

Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bilal Özkardeş, Mine Yavuz Taşlipinar, Mehmet Doğan, Halit Ziya Dündar, Mehmet Kiliç, Arif Ahmet Başaran, Ayşe Nurşen Başaran

Article Affiliation:

Mehmet Tokaç

Abstract:

BACKGROUND/AIM: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats.

MATERIALS AND METHODS: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated.

RESULTS: The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats.

CONCLUSION: These results suggest that lycopene might have protective effects on acute cholestasis.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Hepatoprotective : CK(3182) : AC(1418)

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