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Article Publish Status: FREE
Abstract Title:

In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts ofPlants from Rivers State, Niger Delta, Nigeria.

Abstract Source:

Medicines (Basel). 2018 Jul 5 ;5(3). Epub 2018 Jul 5. PMID: 29976887

Abstract Author(s):

Lucky Legbosi Nwidu, Ekramy Elmorsy, Jonah Sydney Aprioku, Iyeopu Siminialayi, Wayne Grant Carter

Article Affiliation:

Lucky Legbosi Nwidu

Abstract:

This study evaluatedextracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts ofwere evaluated for inhibition of acetylcholinesterase (AChE) activity, antioxidant properties, and total phenolic and flavonoid contents using standard procedures.extracts possessed significant and concentration dependent AChE inhibitory activity for methanolic, aqueous, and ethanolic extracts. For the most potent extracts, the percentage AChE inhibition/IC(µg/mL) values wereroot methanolic extracts (MORME): ~80%/0.00845;root ethanolic extract 1 (MOREE1): ~90%/0.0563;root ethanolic extract 2 (MOREE2): ~70%/0.00175; andbark ethanolic extract (MOBEE): ~70%/0.0173. The descending order of AChE inhibitory potency of plant parts were: root>bark>leaf>flowers>seed. Allmethanolic extracts at a concentration of 1000µg/mL displayed significant (<0.05⁻0.001) DPPH radical scavenging activity, with values of ~20⁻50% of that of ascorbic acid. The total phenolic content and total flavonoid content (TPC/TFC) of MORME,bark methanolic extract (MOBME), MOREE1, MOREE2 and Moringa leaf ethanolic leaf extract (MLEE) were (287/254), (212/113), (223/185), (203/343) and (201/102) mg gallic acid equivalents/g and quercetin equivalents/g, respectively. There was an inverse correlation between plant extract AChE inhibition and total phenolic (<0.0001) and total flavonoid contents (<0.0012). In summary, this study revealed 5 of 19 extracts ofthat have potent in vitro anti-cholinesterase and antioxidant activities.

Study Type : In Vitro Study

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