Article Publish Status: FREE
Abstract Title:

Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study.

Abstract Source:

J Int Med Res. 2018 Aug ;46(8):3327-3336. Epub 2018 Jul 1. PMID: 29962304

Abstract Author(s):

Marisa López, Mónica Ríos-Silva, Miguel Huerta, Yolitzy Cárdenas, Jaime Alberto Bricio-Barrios, María Irene Díaz-Reval, Zorayda Urzúa, Miguel Huerta-Trujillo, Karla López-Quezada, Xóchitl Trujillo

Article Affiliation:

Marisa López


Objective To evaluate the preventive effects of Moringa oleifera on metabolic syndrome (MS) in male Wistar rats. Methods MS was induced by feeding rats a high-fat diet and drinking water containing 10% fructose for 6 weeks. In the preventive group, M. oleifera was orally administered for 3 weeks prior to the induction of MS, while in the treatment group, M. oleifera was administered for 3 weeks after the onset of MS. The treatment groups were compared with a control group of untreated rats with induced MS. Fasting glucose, oral glucose tolerance, insulin tolerance, total cholesterol, triglycerides, abdominal circumference, and systolic and diastolic blood pressure were measured before and after MS induction and/or M. oleifera treatment. Results After the induction of MS, the control group had higher fasting glucose levels than the preventive group. No significant differences were observed in insulin tolerance, oral glucose tolerance, cholesterol, triglycerides, abdominal circumference, or systolic or diastolic blood pressure. Compared with untreated controls, rats in the treatment group had significantly improved glucose tolerance, triglycerides, and abdominal circumference. Conclusions M. oleifera treatment attenuates MS in Wistar rats.

Study Type : Animal Study

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