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Abstract Title:

Effects of magnesium chloride on in vitro cholinesterase and ATPase poisoning by organophosphate (chlorpyrifos).

Abstract Source:

Pharmacol Res Perspect. 2018 Jun ;6(3):e00401. Epub 2018 Apr 30. PMID: 29736246

Abstract Author(s):

Bamidele S Ajilore, Adetayo A Alli, Tolulope O Oluwadairo

Article Affiliation:

Bamidele S Ajilore

Abstract:

The present study investigated possible benefits of magnesium ion (as MgCl) in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes. Blood samples collected from volunteered healthy adult by venepuncture into anticoagulant test tubes containing EDTA were separated into plasma and red blood cell and divided into three groups namely: normal, pesticide only (0.25-2.0 mmol/L chlorpyrifos) and pesticide (0.25-2.0 mmol/L chlorpyrifos) + 0.1 mol/L MgCl. Acetylcholinesterase, Na/KATPase and CaATPase activities were evaluated. Results showed that Chlorpyrifos significantly ( < .05) reduced the levels of cholinesterase both in plasma and on red blood cells. Red blood cells Na/KATPase and CaATPase were also significantly ( < .05) reduced by chlorpyrifos while MgClcounteracted effects of chlorpyrifos with significant ( < .05) increase in the levels of cholinesterase, Na/KATPase and CaATPase. We concluded that MgClneutralized effects of chlorpyrifos by promoting normal ATPase activities and inhibiting release of acetylcholine from cell.

Study Type : Human Study
Additional Links
Substances : magnesium chloride
Problem Substances : Chlorpyrifos : CK(12) : AC(2)

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