Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy.
Pain Manag. 2016 Nov 21. Epub 2016 Aug 21. PMID: 27866449
AIM: This research was carried out to compare magnesium sulfate (MgSO4) with isotonic saline in terms of pain control after herniorrhaphy.
PATIENTS & METHODS: A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO4 in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively.
RESULT: The administration of postoperative morphine in control group 0.79± 1.48 mg was significantly higher to the experimental group 0.17 ± 0.63 mg during the first 24 h (p = 0.01).
CONCLUSION: MgSO4 increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.