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Article Publish Status: FREE
Abstract Title:

TheRadiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma.

Abstract Source:

In Vivo. 2020 Jul-Aug;34(4):1789-1796. PMID: 32606148

Abstract Author(s):

Yu-Shan Chen, Rou Sun, Wei-Lung Chen, Yu-Chen Yau, Fei-Ting Hsu, Jing-Gung Chung, Chia-Jung Tsai, Chia-Ling Hsieh, Ying-Ming Chiu, Jiann-Hwa Chen

Article Affiliation:

Yu-Shan Chen

Abstract:

BACKGROUND/AIM: Radiation (RT) induced ERK/NF-κB in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-κB inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have anti-inflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo.

MATERIALS AND METHODS: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT.

RESULTS: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-κB-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and -9, were markedly increased in the combination group.

CONCLUSION: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NF-κB-related proteins and increasing the expression of apoptosis-related proteins.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Radiosensitizer : CK(244) : AC(142)

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