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Article Publish Status: FREE
Abstract Title:

A Comparison of Cytotoxic Effects ofL. andExtract on Human Chronic Lymphocytic Leukemia.

Abstract Source:

Iran J Pharm Res. 2019 ;18(4):1843-1853. PMID: 32184851

Abstract Author(s):

Abdollmajid Ayatollahi, Jalil Rahmati, Ahmad Salimi, Jalal Pourahmad

Article Affiliation:

Abdollmajid Ayatollahi

Abstract:

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango ( L.) andare thought to be rich of functional phytochemicals. To clarify the anticancer activity, aqueous extracts ofnut and fruit were exanimated on chronic lymphocytic leukemia (CLL) B lymphocytes and their mitochondria and the results were compared with those of normal B lymphocytes. Cellular parameters such as viability and caspase 3 activity, and mitochondrial parameters such as reactive oxygen species (ROS), mitochondria membrane potential (MMP), mitochondrial swelling, and cytochrome c release were evaluated. Our results demonstrated that the extract of L increased cytotoxicity and caspase 3 activation through mitochondria pathway only in CLL B lymphocytes and also the extract ofdid not show cytotoxicity and caspase 3 activation on CLL and healthy B lymphocytes. Ourfindings on isolated mitochondria indicated that mitochondrial ROS formation, MMP collapse, and mitochondrial swelling and cytochrome c release were significantly (<0.05) increased after addition of only in cancerous mitochondria. These results demonstrated that can act as a promising source for anti-cancer drug candidates by directly and selectively targeting mitochondria and inducing selective mitochondria mediated apoptosis on CLL B lymphocytes.

Study Type : In Vitro Study

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Sayer Ji
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