Mangifera Indica can act promising source for anti-cancer treatment candidate. - GreenMedInfo Summary
A Comparison of Cytotoxic Effects ofL. andExtract on Human Chronic Lymphocytic Leukemia.
Iran J Pharm Res. 2019 ;18(4):1843-1853. PMID: 32184851
Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango ( L.) andare thought to be rich of functional phytochemicals. To clarify the anticancer activity, aqueous extracts ofnut and fruit were exanimated on chronic lymphocytic leukemia (CLL) B lymphocytes and their mitochondria and the results were compared with those of normal B lymphocytes. Cellular parameters such as viability and caspase 3 activity, and mitochondrial parameters such as reactive oxygen species (ROS), mitochondria membrane potential (MMP), mitochondrial swelling, and cytochrome c release were evaluated. Our results demonstrated that the extract of L increased cytotoxicity and caspase 3 activation through mitochondria pathway only in CLL B lymphocytes and also the extract ofdid not show cytotoxicity and caspase 3 activation on CLL and healthy B lymphocytes. Ourfindings on isolated mitochondria indicated that mitochondrial ROS formation, MMP collapse, and mitochondrial swelling and cytochrome c release were significantly (<0.05) increased after addition of only in cancerous mitochondria. These results demonstrated that can act as a promising source for anti-cancer drug candidates by directly and selectively targeting mitochondria and inducing selective mitochondria mediated apoptosis on CLL B lymphocytes.