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Abstract Title:

Mangiferin antagonizes TNF-α-mediated inflammatory reaction and protects against dermatitis in a mice model.

Abstract Source:

Int Immunopharmacol. 2017 Feb 18 ;45:174-179. Epub 2017 Feb 18. PMID: 28222357

Abstract Author(s):

Yunpeng Zhao, Wenhan Wang, Xihai Wu, Xiaoqian Ma, Ruize Qu, Xiaomin Chen, Chenghao Liu, Yaoge Liu, Xiaokai Wang, Pengcheng Yan, Hao Zhang, Jingrui Pan, Weiwei Li

Article Affiliation:

Yunpeng Zhao

Abstract:

This study aimed to investigate whether mangiferin played a protective role in a well-established dermatitis mouse model and tumor necrosis factor alpha (TNF-α)-induced RAW264.7 macrophages. Contact dermatitis is an inflammatory skin disease in the clinic, while its underlying mechanism still remains to be elucidated. Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-d-glucoside (C-glucosyl xanthone), a natural antioxidant that was reported to inhibit inflammatory reactions, has been recently proved to be a potential therapy for inflammation. As a result, the oxazolone-induced dermatitis mice models were established to explore whether mangiferin has an anti-inflammatory role in vivo. The phosphate-buffered saline treatment groups showed emblematic skin inflammation, whereas the administration of mangiferin obviously inhibited dermatitis in the mice models. Furthermore, exogenous mangiferin alleviated the inflammatory reaction in TNF-α-induced macrophages by suppressing the production of inflammation- and oxidative stress-associated molecules.Also, mangiferin treatment repressed the activation of nuclear factor-kappaB signaling pathway. To sum up, mangiferin could provide a new target for the therapy and prevention of skin inflammation.

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