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Abstract Title:

Mangiferin: An effective therapeutic agent against several disorders (Review).

Abstract Source:

Mol Med Rep. 2018 Oct 2. Epub 2018 Oct 2. PMID: 30280187

Abstract Author(s):

Suya Du, Huirong Liu, Tiantian Lei, Xiaofang Xie, Hailian Wang, Xia He, Rongsheng Tong, Yi Wang

Article Affiliation:

Suya Du

Abstract:

Mangiferin (1,3,6,7‑tetrahydroxyxanthone‑C2‑β‑D‑glucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, anti‑hyperuricemic,neuroprotective, antioxidant, anti‑inflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several health‑endorsing properties and is a promising candidate for further research and development. However, low solubility, mucosal permeability and bioavailability restrict the development of mangiferin as a clinical therapeutic, and chemical and physical modification is required to expand its application. This review comprehensively analyzed and collectively summarized the primary pharmacological actions of mangiferin that have been demonstrated in the literature, to support the potential future development of mangiferin as a novel therapeutic drug.

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