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Abstract Title:

Antidiabetic activity of a xanthone compound, mangiferin.

Abstract Source:

Phytomedicine. 2001 Mar;8(2):85-7. PMID: 11315760

Abstract Author(s):

T Miura, H Ichiki, I Hashimoto, N Iwamoto, M Kato, M Kubo, E Ishihara, Y Komatsu, M Okada, T Ishida, K Tanigawa

Article Affiliation:

Suzuka University of Medical Science, Mie, Japan.

Abstract:

Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p<0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.

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Sayer Ji
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