Abstract Title:

Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods.

Abstract Source:

Pharm Biol. 2010 Feb;48(2):182-6. PMID: 20645837

Abstract Author(s):

Werayut Pothitirat, Mullika Traidej Chomnawang, Roongtawan Supabphol, Wandee Gritsanapan

Article Affiliation:

Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Abstract:

The ethanol extracts of mangosteen fruit rinds prepared by several extraction methods were examined for their contents of bioactive compounds, DPPH-scavenging activity, and anti-acne producing bacteria against Propionibacterium acnes and Staphylococcus epidermidis. The dried powder of the fruit rind was extracted with 95% ethanol by maceration, percolation, Soxhlet extraction, ultrasonic extraction, and extraction using a magnetic stirrer. Soxhlet extraction promoted the maximum contents of crude extract (26.60% dry weight) and alpha-mangostin (13.51%, w/w of crude extract), and also gave the highest anti-acne activity with MIC 7.81 and 15.63 microg/mL and MBC 15.53 and 31.25 microg/mL against P. acnes and S. epidermidis, respectively. Ethanol 70% and 50% (v/v) were also compared in Soxhlet extraction. Ethanol 50% promoted the extract with maximum amounts of total phenolic compounds (26.96 g gallic acid equivalents/100 g extract) and total tannins (46.83 g tannic acid equivalents/100 g extract), and also exhibited the most effective DPPH-scavenging activity (EC(50) 12.84 microg/mL). Considering various factors involved in the process, Soxhlet extraction carried a low cost in terms of reagents and extraction time. It appears to be the recommended extraction method for mangosteen fruit rind. Ethanol 50% should be the appropriate solvent for extracting free radical-scavenging components, phenolic compounds, and tannins, while 95% ethanol is recommended for extraction of alpha-mangostin, a major anti-acne component from this plant.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)

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