Abstract Title:

Antiproliferative and apoptosis induction ofα-mangostin in T47D breast cancer cells.

Abstract Source:

Int J Oncol. 2016 Feb 18. Epub 2016 Feb 18. PMID: 26892433

Abstract Author(s):

Somchai Kritsanawong, Sukanda Innajak, Masaya Imoto, Ramida Watanapokasin

Article Affiliation:

Somchai Kritsanawong

Abstract:

α-Mangostin extracted from mangosteen, Garcinia mangostana Linn. is known as 'queen of fruits'. The anticancer activity of α-mangostin through apoptosis induction and related signaling pathways in human breast cancer T47D cells was investigated. Human epidermal growth factor receptor 2 (HER2) andmitogen-activated protein kinase (MAPK) signaling have been shown to play important roles in apoptosis. The results showed that α-mangostin induced cell proliferation inhibition, DNA fragmentation, nuclear condensation, increased cleaved caspase-3 and cleaved caspase-9, but decreased Bcl-2 and Mcl-1 expression. Mitochondrial dysfunction and cytochrome c release were also detected. In addition, phosphorylation of ERα, HER2, PI3K, Akt and ERK1/2 were downregulated whereas p-JNK1/2 and p-p38 were upregulated. These results indicated that α-mangostin induced apoptosis associated with HER2/PI3K/Akt and MAPK signaling pathways suggesting that α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.

Study Type : Human In Vitro

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