Article Publish Status: FREE
Abstract Title:

Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation ofWound-Healing and Anti-Inflammatory Activities.

Abstract Source:

Pharmaceuticals (Basel). 2020 May 14 ;13(5). Epub 2020 May 14. PMID: 32423026

Abstract Author(s):

Gabriele Carullo, Fabio Sciubba, Paolo Governa, Sarah Mazzotta, Luca Frattaruolo, Giorgio Grillo, Anna Rita Cappello, Giancarlo Cravotto, Maria Enrica Di Cocco, Francesca Aiello

Article Affiliation:

Gabriele Carullo


The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorellowere extracted in a Soxhlet apparatus, using-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayedas wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively.-hexane Mantonico extract resulted in the most interesting wound healing sample, while-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties.

Study Type : In Vitro Study

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