Abstract Title:

Comparison of the effects of marchantin C and fucoidan on sFlt-1 and angiogenesis in glioma microenvironment.

Abstract Source:

J Pharm Pharmacol. 2012 Apr ;64(4):604-9. Epub 2012 Feb 7. PMID: 22420666

Abstract Author(s):

Yafeng Lv, Qingxu Song, Qianqian Shao, Wenjuan Gao, Haiting Mao, Hongxiang Lou, Xun Qu, Xingang Li

Article Affiliation:

Department of Neurosurgery Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, China.


OBJECTIVES: This study aimed to examine the effects of marchantin C and fucoidan on angiogenesis induced by glioma cells and monocytes, and to elucidate the role of sFlt-1 in this process.

METHODS: T98G glioma cells and THP1 monocytes were pretreated with marchantin C or fucoidan, respectively. Conditioned media were used for endothelial cell tube formation assay and detection of sFlt-1 by ELISA. Depletion of sFlt-1 was achieved by a neutralizing antibody to assess its role in the process.

KEY FINDINGS: Marchantin C inhibited angiogenesis induced by T98G cells while fucoidan inhibited both T98G and THP1 cell-induced angiogenesis. In all three groups in which angiogenesis was inhibited, sFlt-1 level in the supernatants was elevated. Pretreatment of the conditioned media with sFlt-1 antibody restored the inhibited angiogenesis to a certain degree.

CONCLUSIONS: This study suggested for the first time that marchantin C and fucoidan could significantly inhibit angiogenesis induced by glioma cells or monocytes. Up-regulation of sFlt-1 played an important role in this process.

Study Type : In Vitro Study

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Sayer Ji
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