n/a
Article Publish Status: FREE
Abstract Title:

Marine AlgaExtract and Dieckol Attenuate Prostaglandin EProduction in HaCaT Keratinocytes Exposed to Airborne Particulate Matter.

Abstract Source:

Antioxidants (Basel). 2019 Jun 21 ;8(6). Epub 2019 Jun 21. PMID: 31234405

Abstract Author(s):

Jae Won Ha, Hyerim Song, Seong Su Hong, Yong Chool Boo

Article Affiliation:

Jae Won Ha

Abstract:

Atmospheric particulate matter (PM) is an important cause of skin damage, and an increasing number of studies have been conducted to discover safe, natural materials that can alleviate the oxidative stress and inflammation caused by PM. It has been previously shown that the extract ofKjellman, a perennial brown macroalga, can alleviate oxidative stress in epidermal keratinocytes exposed to PM less than 10 microns in diameter (PM10). The present study was undertaken to further examine the anti-inflammatory effects ofextract and its major polyphenolic constituent, dieckol. HaCaT keratinocytes were exposed to PM10 in the presence or absence ofextract or dieckol and analyzed for their viability, prostaglandin E(PGE) release, and gene expression of cyclooxygenase (COX)-1, COX-2, microsomal prostaglandin Esynthase (mPGES)-1, mPGES-2, and cytosolic prostaglandin Esynthase (cPGES). PM10 treatment decreased cell viability and increased the production of PGE, and these changes were partially abrogated byextract.extract also attenuated the expression of COX-1, COX-2, and mPGES-2 stimulated by PM10. Dieckol attenuated PGEproduction and the gene expression of COX-1, COX-2, and mPGES-1 stimulated by PM10. This study demonstrates thatextract and dieckol alleviate airborne PM10-induced PGEproduction in keratinocytes through the inhibition of gene expression of COX-1, COX-2, mPGES-1, and/or mPGES-2. Thus,extract and dieckol are potentially useful natural cosmetic ingredients for counteracting the pro-inflammatory effects of airborne PM.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.