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Abstract Title:

Mass spectrometry-based phytochemical screening for hypoglycemic activity of Fagioli di Sarconi beans (Phaseolus vulgaris L.).

Abstract Source:

Food Chem. 2018 Mar 1 ;242:497-504. Epub 2017 Sep 19. PMID: 29037720

Abstract Author(s):

Raffaella Pascale, Giuliana Bianco, Tommaso R I Cataldi, Philippe-Schmitt Kopplin, Federica Bosco, Lisiana Vignola, Jenny Uhl, Marianna Lucio, Luigi Milella

Article Affiliation:

Raffaella Pascale

Abstract:

The present study deals with the evaluation of antidiabetic activities of Fagioli di Sarconi beans (Phaseolus vulgaris), including 21 ecotypes protected by the European Union with the mark PGI (i.e., Protected Geographical Indication), and cultivated in Basilicata (southern Italy). For this purpose,α-glucosidase and α-amylase assays were assessed; among all bean ecotypes, the tight green seed colour of Verdolino extracts exhibited the highest α-glucosidase and α-amylase inhibitory activity with IC50=1.1±0.1μg/ml and IC50=19.3±1.1μg/ml, respectively. Phytochemical compound screening ofall Fagioli di Sarconi beans performed by flow injection-electrospray ionization-ultrahigh resolution mass spectrometry (uHRMS) and based on the calculation of elemental formulas from accurate m/z values, was helpful to annotate specific compounds, such as alkaloids, saponins, flavonoids, and terpenoids, which are most likely responsible for their biological activity.

Study Type : In Vitro Study

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