Abstract Title:

Maternal Garlic Oil Supplementation Prevents High-Fat Diet-induced Hypertension in Adult Rat Offspring: Implications of H2S-generating Pathway in the Gut and Kidneys.

Abstract Source:

Mol Nutr Food Res. 2021 Feb 5:e2001116. Epub 2021 Feb 5. PMID: 33547712

Abstract Author(s):

Chien-Ning Hsu, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, You-Lin Tain

Article Affiliation:

Chien-Ning Hsu


SCOPE: Perinatal high-fat (HF) diet induces hypertension in adult offspring. Garlic, a naturally dietary source of Hydrogen sulfide (HS) donor, has been shown benefits in hypertension. We examined whether maternal garlic oil supplementation can prevent hypertension induced by HF diet and elucidated its protective effects.

METHODS AND RESULTS: Pregnant rats received either a normal diet or HF diet. Rat dams were given garlic oil or vehicle daily by oral gavage at 100 mg/kg/day during pregnancy and lactation. Male offspring were sacrificed at 16 weeks of age. Garlic oil supplementation during pregnancy and lactation protected against hypertension induced by HF diet in adult male offspring. The beneficial effects of garlic oil were associated with increased renal mRNA expression and activity of HS-generating enzymes, increased NO bioavailability, increased plasma short chain fatty acid levels, and alterations of gut microbiota composition. Garlic oil supplementation increased abundance of genus Lactobacillus, but decreased genera Turicibacter and Staphylococcus.

CONCLUSION: Our data revealed associations between HS-generating pathway in the gut and kidneys, NO system, gut microbiota, and microbiota-derived metabolites in hypertension induced by HF intake and provided insight to garlic oil as a hypertension reprogramming strategy for further translational research. This article is protected by copyright. All rights reserved.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.