Abstract Title:

Maternal western style diet increases susceptibility to chemically-induced mammary carcinogenesis in female rats offspring.

Abstract Source:

Nutr Cancer. 2014 ;66(8):1293-303. Epub 2014 Oct 21. PMID: 25333700

Abstract Author(s):

Gisele A D Lopes, William Y C Fan, Heloisa Ciol, Lucas T Bidinotto, Maria A M Rodrigues, Luís F Barbisan

Article Affiliation:

Gisele A D Lopes


The present study investigated whether maternal exposure to western style diet (WD) increases susceptibility to mammary carcinogenesis induced by N-methyl-N-nitrosourea (MNU) in female offspring. Pregnant female Sprague-Dawley rats received WD diet or control diet from gestational day 12 until postnatal day (PND) 21. At PND 21, female offspring received a single dose of MNU (50 mg/kg body weight) and were fed chow diet until PND 110. Mammary gland structures were assessed on whole-mount preparations in the offspring at PND 21, and tumor morphology was examined at PND 110. Immunohistochemical analysis for cell proliferation (PCNA), apoptosis (cleaved caspase-3) and estrogen receptor alpha (ER-α) was performed in mammary terminal end buds (TEBs) at PND 21, and PCNA, ER-α, and p63 analysis in mammary tumors at PND 110. Maternal WD intake induced a significant increase in the number of TEBs (P = 0.024) and in PCNA labeling index (P<0.020) in the mammary glands at PND 21. Tumor multiplicity, tumor weight, and PCNA labeling indexes were significantly higher in the WD offspring than that of the control offspring (P<0.05). These findings indicate that maternal western style diet potentially enhanced the development of mammary tumors induced by MNU in female offspring, possibly by affecting the mammary gland differentiation.

Study Type : Animal Study
Additional Links
Anti Therapeutic Actions : Western Diet : CK(416) : AC(121)

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