Melatonin and regulation of autophagy: Mechanisms and therapeutic implications - GreenMedInfo Summary
Melatonin and regulation of autophagy: Mechanisms and therapeutic implications.
Pharmacol Res. 2020 Nov 5:105279. Epub 2020 Nov 5. PMID: 33161138
Mitochondria are essential subcellular units that generate basic energy for the cell, as well as influence Caflux, apoptosis, and cell signaling. Mitophagy can selectively remove impaired mitochondria to preserve mitochondrial function, which is crucial for normal cellular maintenance. Mitochondrial dysfunction and mitophagy are widely reported to be linked to various pathogeneses. In addition, there is increasing evidence regarding the beneficial role of melatonin in the regulation and intervention of mitophagy progression. In this review, we focus on specific pathological conditions, including ischemia/reperfusion injury (IRI), cancer and neurodegenerative diseases, and elucidate the essential role of melatonin in the modulation of mitophagy in each of these distinct disorders.