Abstract Title:

Pleiotropic protective roles of melatonin against aluminium-induced toxicity in rats.

Abstract Source:

Gen Physiol Biophys. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26374992

Abstract Author(s):

Mohamed S Allagui, Rafik Hachani, Saber Saidi, Anouer Feriani, Jean C Murat, Kamel Kacem, Abdelfatteh El Feki

Article Affiliation:

Mohamed S Allagui


This study aimed to investigate the potential effects of melatonin on aluminium-induced toxicity in a rat model using a set of biochemical, inflammatory, oxidant, lipid profile criteria and hepatic integrity (verified by hematoxylin-eosin staining). The results indicated that AlCl3 administration during 60 days (100 mg/kg b.w.) significantly increased the activities of transaminases AST and ALT by 46% (p<0.001) and 21% (p<0.01), lactate dehydrogenase (LDH) by 30% (p<0.001), the levels of bilirubin by 85% (p<0.001), total cholesterol by 115% (p<0.001), triglycerides by130% (p<0.001), LDL-cholesterol by 413% (p<0.001), oxidized LDL (oxLDL) by 51% (p<0.01) and apolipoprotein B100 (apoB100) by 63% (p<0.001), as compared to controls. The inflammatory markers (TNF-α, IL-2, and IL-6) were significantly increased (p<0.001), associated to higher lipid peroxidation (TBARS) level. Also, both plasma HDL-cholesterol level and hepatic LDL receptors (p<0.01) expression and antioxidant protein (SOD, CAT, and GPx) activities are decreased. Those physiological disturbances were, however, noted to alleviate following the co-administration of melatonin (10 mg/kg b.w.). Overall, the present study is the first to provide evidence on the anti-inflammatory, anti-oxidant, anti-lipidic and, hence, therapeutic effects of melatonin with regard to the control and prevention of aluminium-intoxication.

Study Type : Animal Study

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