Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes.
Chronobiol Int. 2019 Dec 2:1-12. Epub 2019 Dec 2. PMID: 31790604
The present study aimed to investigate whether nocturnal melatonin (MEL) ingestion has beneficial effects against exercise-induced oxidative stress and muscle damage in young athletes. Fourteen healthy-trained teenagers performed two-test sessions separated by at least, 1 week. During each session, participants completed the Running-Based Anaerobic Sprint Test (RAST) at 20:00 h. Then, they ingested a single 10-mg tablet of MEL or Placebo (PLA) in a double-blind randomized order at 22:00 h. The following morning (i.e., 07:30 h), participants performed the same test as the previous night. Blood samples were taken before and after exercise. MEL intake increased the peak power (P) (<.01), mean power (P) (<.001) and decreased the total time (TT) (<.001) and the fatigue index (FI) (<.05). Furthermore, MEL ingestion attenuated the hematologic parameters before and after exercise (White Blood Cells (WBC:<.001 and<.001, respectively); Neutrophiles (NE:<.001 and<.001, respectively); Lymphocytes (LY:<.001 and<.001, respectively)) and the ultra-sensitive C-reactive protein (us-CRP:<.001 and<.001; respectively) compared to PLA. Also, MEL reduced muscle and hepatic damage enzymes before and after exercise (creatine kinase (CK:<.001 and<.001; respectively), lactate dehydrogenase (LDH:<.05 and<.01; respectively), aspartate aminotransferase (ASAT:<.01 and<.001; respectively)),(MDA:<.001 and<.001; respectively) and Homocysteine (Hcy:<.001 and<.001; respectively)) from placebo. Plasma lactate [La] and glucose (GL) remained unchangeable during the two conditions. In summary, acute MEL ingestion after strenuous late-evening exercise attenuated transient leucocytosis and protected against lipid peroxidation and muscle damage induced by strenuous exercise the following morning in healthy male teenage athletes.