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Abstract Title:

Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.

Abstract Source:

J Pineal Res. 2006 Nov;41(4):313-23. PMID: 17014688

Abstract Author(s):

Jochen H Weishaupt, Claudia Bartels, Esther Pölking, Jeannine Dietrich, Gundula Rohde, Burkhard Poeggeler, Nina Mertens, Swetlana Sperling, Matthias Bohn, Gerald Hüther, Armin Schneider, Alfred Bach, Anna-Leena Sirén, Rüdiger Hardeland, Mathias Bähr, Klaus-Armin Nave, Hannelore Ehrenreich

Abstract:

Amyotrophic lateral sclerosis (ALS) is the collective term for a fatal motoneuron disease of different etiologies, with oxidative stress as a common molecular denominator of disease progression. Melatonin is an amphiphilic molecule with a unique spectrum of antioxidative effects not conveyed by classical antioxidants. In preparation of a possible future clinical trial, we explored the potential of melatonin as neuroprotective compound and antioxidant in: (1) cultured motoneuronal cells (NSC-34), (2) a genetic mouse model of ALS (SOD1(G93A)-transgenic mice), and (3) a group of 31 patients with sporadic ALS. We found that melatonin attenuates glutamate-induced cell death of cultured motoneurons. In SOD1(G93A)-transgenic mice, high-dose oral melatonin delayed disease progression and extended survival. In a clinical safety study, chronic high-dose (300 mg/day) rectal melatonin was well tolerated during an observation period of up to 2 yr. Importantly, circulating serum protein carbonyls, which provide a surrogate marker for oxidative stress, were elevated in ALS patients, but were normalized to control values by melatonin treatment. This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS.

Study Type : In Vitro Study

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Sayer Ji
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