Article Publish Status: FREE
Abstract Title:

Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.

Abstract Source:

Int J Environ Res Public Health. 2016 ;13(3). Epub 2016 Feb 29. PMID: 26938543

Abstract Author(s):

Yufei Mei, Chunli Duan, Xiaoxiao Li, Yun Zhao, Fenghua Cao, Shuai Shang, Shumao Ding, Xiangpei Yue, Ge Gao, Hui Yang, Luxi Shen, Xueyan Feng, Jianping Jia, Zhiqian Tong, Xu Yang

Article Affiliation:

Yufei Mei


Individuals afflicted with occupational formaldehyde (FA) exposure often suffer from abnormal behaviors such as aggression, depression, anxiety, sleep disorders, and in particular, cognitive impairments. Coincidentally, clinical patients with melatonin (MT) deficiency also complain of cognitive problems associated with the above mental disorders. Whether and how FA affects endogenous MT metabolism and induces cognitive decline need to be elucidated. To mimic occupational FA exposure environment, 16 healthy adult male mice were exposed to gaseous FA (3 mg/m³) for 7 consecutive days. Results showed that FA exposure impaired spatial memory associated with hippocampal neuronal death. Biochemical analysis revealed that FA exposure elicited an intensive oxidative stress by reducing systemic glutathione levels, in particular, decreasing brain MT concentrations. Inversely, intraperitoneal injection of MT markedly attenuated FA-induced hippocampal neuronal death, restored brain MT levels, and reversed memory decline. At tissue levels, injection of FA into the hippocampus distinctly reduced brain MT concentrations. Furthermore, at cellular and molecularlevels, we found that FA directly inactivated MT in vitro and in vivo. These findings suggest that MT supplementation contributes to the rescue of cognitive decline, and may alleviate mental disorders in the occupational FA-exposed human populations.

Study Type : Animal Study

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